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Three Key Vitamins and Why You Need Them

By: Keifer Williams

The conventional wisdom is that vitamins are good for us, and that conventional wisdom would be correct. Vitamins are important to our overall health because they are used to perform many different tasks within the body.

We can get vitamins we need from the foods we eat, but can you honestly say you eat the recommended amounts of fruits and vegetables EVERY DAY? If you’re answer is no, you’re not alone.

That’s why we have thousands of vitamin supplements on the market. That’s why there are entire stores dedicated to selling vitamins.  But how are we supposed to know where to begin?

This article will explain 3 key vitamins, their benefits, and why it’s important to obtain them from a quality source.

Methylfolate shutterstock_342455411

Methylfolate is the activated form of Folic acid. Folic acid is a B vitamin that’s involved in a multitude of chemical reactions in the body. Generally, in the body, folate is transformed by an enzyme called methylene tetrahydrofolate reductase (MTHFR) to the activated form methylfolate.

Unfortunately, in as many as 40% of the general population there may be some form of mutation in the MTHFR enzyme which alters how it would normally work. When this enzyme does not function correctly then a situation arises where folic acid that is taken in through diet or through supplementation isn’t as effective in addressing the body’s needs.

Methylfolate solves this problem by skipping the step in the metabolism that utilizes the MTHFR enzyme. Since the methylfolate is already activated then there is no need for the body to do so. This allows the supplement to exert its actions in spite of any defect in the enzyme’s gene.

What is methylfolate used for in the body?

Folate is a vital part of the body’s metabolism. Folate supplements are useful for a wide variety of ailments, but recently have been recognized to be connected to mental health. Methylfolate is implicated in prevention and treatment of mental health conditions such as Depression, Alzheimer’s, Bipolar Disorder, Parkinson’s disease, and Schizophrenia.

Methylfolate is also involved in one of the body’s natural metabolic pathways called methylation. This pathway regulates the body’s production of methionine from homocysteine. Too much homocysteine in the body is correlated with poor cardiovascular health. Involvement in the methylation pathway also gives this supplement downstream action to promote hormone balance and help those with neuropathy.


Methylcobalamin is the activated form of Vitamin B12. The body must first activate B12 in a similar fashion to how it would folic acid.  Individuals with the same MTHFR mutation that affects folic acid will also fail to metabolize vitamin B12 appropriately. (Remember, up to 40% of the population of a mutation in the gene that causes MTHFR to not function properly.)

What is methylcobalamin used for in the body?

Normally vitamin B12 and folate work in tandem to produce Methionine from Homocysteine. As we’ve mentioned before high homocysteine levels have been implicated in cardiovascular disease and stroke, and methylcobalamin supplementation will reduce homocysteine levels.

Methylcobalamin is also indicated for individuals who suffer from pernicious anemia as a medical treatment. Pernicious anemia is a condition in which the body has fewer red blood cells because it is deficient in Vitamin B12.

Vitamin D3 (Cholecalciferol)shutterstock_390178054

Vitamin D3 is an important component in maintaining good bone health. Vitamin D3 increases the body’s ability to absorb calcium, which is one of the main elements used to construct bone. Vitamin D3 is normally made by the body in the skin upon exposure to sunlight and some amount can be absorbed through the diet.

What is Vitamin D3 used for in the body?

Besides is effect on promoting strong bones, the National Institute of Health states there is evidence that adequate vitamin D3 levels may be protective against several cancers such as colon, prostate, and breast cancer.

Cholecalciferol has also been shown to support immune system function and improve energy levels.

Where can I get these 3 key vitamins?

As we’ve mentioned before, there are tens of thousands of supplements on the market, and hundreds of different supplement companies. They’re all essentially the same, right? NO! All supplements are not created equal. It’s important to take a high quality supplement from a high quality brand that maintains high standards for their products.

Collier Compounding takes pride in being a high quality and trusted source for your custom health care needs.

As of yet, no major supplement company has developed a combination product with these 3 key vitamins in them. Collier Compounding, however, offers a single dose sublingual tablet with all 3 of these ingredients working together. We call it MMD.

Who can benefit from MMD?

MMD therapy has the many benefits discussed above. As already mentioned 40% of the population may suffer from an MTHFR mutation, almost all unbeknownst to the individual. These individuals can find many health benefits from methylfolate and methylcobalamin, especially mental health.

There is evidence the MTHFR mutation is implicated in many mental health disorders and methylfolate seems to be a component necessary for a fully-functioning healthy mind. Methylfolate improves the body’s ability to produce neurotransmitters, which transmit information in the brain.

Vitamin D3 promotes bone health and is important for all women to have adequate amounts of as they are at the highest risk for osteoporosis. As humans age we lose the ability to manufacture vitamin D3 as efficiently in our skin, therefore it becomes important to make sure we’re receiving enough Vitamin D3 daily to keep bones strong and healthy. Individuals who don’t get much sunlight normally also can benefit from vitamin D3 supplementation, as sunlight is required for the skin to manufacture vitamin D3. Vitamin D3 also shows some evidence as being a cancer preventative for breast, colon, and prostate cancers.

Tell me more about MMD

MMD (Methylcobalamin/Methylfolate/Vitamin D3) is a custom compounding option made in our compounding lab in a convenient sublingual tablet.

Our standard dose of MMD contains 5mg of methylfolate and 5mg of methylcobalamin and 5000 units of Vitamin D3.

Methylfolate and Methylcobalamin are what are known as water-soluble vitamins. This means that the body does not store these vitamins, but excretes any extra it doesn’t use at the time. For this reason, it’s important that our bodies receive an adequate amount of these vitamins each day.

Vitamin D3 is known as a fat-soluble vitamin. This means that the body can store this vitamin in its tissues. The 5000 units taken daily is what is typically necessary for the average person to maintain a proper vitamin d blood level.

There are a couple of other products that are commercially manufactured that will provide some of the ingredients found in MMD. Metanx™ is a commercial tablet that contains methylcobalamin and methylfolate, but not vitamin D3. Metanx™ is often not covered by insurance and will cost around $100 per month. Deplin™ is another product that just contains methylfolate and will generally set you back about $75.

At Collier Compounding, our MMD will cost you around $45 for a full month’s supply. Also, because we can customize the strength, we can adjust the strength of your MMD based on your specific needs.  MMD requires a prescription from your doctor, so discuss with them if MMD would be a good option for you.

If you or your doctor have any questions for us, please don’t hesitate to contact us at our Collier Compounding location.